Targeting Non-proteolytic Protein Ubiquitination for the Treatment of Diffuse Large B Cell Lymphoma

Chronic active B cell receptor (BCR) signaling, a hallmark of the activated B cell-like (ABC) subtype of diffuse large B cell lymphoma (DLBCL), engages the CARD11-MALT1-BCL10 (CBM) adapter complex to activate IκB kinase (IKK) and the classical NF-κB pathway. Here we show that the CBM complex include...

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Publicado no:Cancer Cell
Main Authors: Yang, Yibin, Kelly, Priscilla, Shaffer, Arthur L, Schmitz, Roland, Yoo, Hee Min, Liu, Xinyue, Huang, Da Wei, Webster, Daniel, Young, Ryan M., Nakagawa, Masao, Ceribelli, Michele, Wright, George W., Yang, Yandan, Zhao, Hong, Yu, Xin, Xu, Weihong, Chan, Wing C., Jaffe, Elaine S., Gascoyne, Randy D., Campo, Elias, Rosenwald, Andreas, Ott, German, Delabie, Jan, Rimsza, Lisa, Staudt, Louis M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6026033/
https://ncbi.nlm.nih.gov/pubmed/27070702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2016.03.006
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