JAK1/2 inhibition with baricitinib in the treatment of autoinflammatory interferonopathies

BACKGROUND. Monogenic IFN–mediated autoinflammatory diseases present in infancy with systemic inflammation, an IFN response gene signature, inflammatory organ damage, and high mortality. We used the JAK inhibitor baricitinib, with IFN-blocking activity in vitro, to ameliorate disease. METHODS. Betwe...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Sanchez, Gina A. Montealegre, Reinhardt, Adam, Ramsey, Suzanne, Wittkowski, Helmut, Hashkes, Philip J., Berkun, Yackov, Schalm, Susanne, Murias, Sara, Dare, Jason A., Brown, Diane, Stone, Deborah L., Gao, Ling, Klausmeier, Thomas, Foell, Dirk, de Jesus, Adriana A., Chapelle, Dawn C., Kim, Hanna, Dill, Samantha, Colbert, Robert A., Failla, Laura, Kost, Bahar, O’Brien, Michelle, Reynolds, James C., Folio, Les R., Calvo, Katherine R., Paul, Scott M., Weir, Nargues, Brofferio, Alessandra, Soldatos, Ariane, Biancotto, Angelique, Cowen, Edward W., Digiovanna, John J., Gadina, Massimo, Lipton, Andrew J., Hadigan, Colleen, Holland, Steven M., Fontana, Joseph, Alawad, Ahmad S., Brown, Rebecca J., Rother, Kristina I., Heller, Theo, Brooks, Kristina M., Kumar, Parag, Brooks, Stephen R., Waldman, Meryl, Singh, Harsharan K., Nickeleit, Volker, Silk, Maria, Prakash, Apurva, Janes, Jonathan M., Ozen, Seza, Wakim, Paul G., Brogan, Paul A., Macias, William L., Goldbach-Mansky, Raphaela
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Clinical Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6026004/
https://ncbi.nlm.nih.gov/pubmed/29649002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI98814
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