Fas ligand promotes an inducible TLR-dependent model of cutaneous lupus–like inflammation

Toll-like receptors TLR7 and TLR9 are both implicated in the activation of autoreactive B cells and other cell types associated with systemic lupus erythematosus (SLE) pathogenesis. However, Tlr9(–/–) autoimmune-prone strains paradoxically develop more severe disease. We have now leveraged the negat...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Mande, Purvi, Zirak, Bahar, Ko, Wei-Che, Taravati, Keyon, Bride, Karen L., Brodeur, Tia Y., Deng, April, Dresser, Karen, Jiang, Zhaozhao, Ettinger, Rachel, Fitzgerald, Katherine A., Rosenblum, Michael D., Harris, John E., Marshak-Rothstein, Ann
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6025993/
https://ncbi.nlm.nih.gov/pubmed/29889098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI98219
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