The H3K4 methyltransferase Setd1b is essential for hematopoietic stem and progenitor cell homeostasis in mice

Hematopoietic stem cells require MLL1, which is one of six Set1/Trithorax-type histone 3 lysine 4 (H3K4) methyltransferases in mammals and clinically the most important leukemia gene. Here, we add to emerging evidence that all six H3K4 methyltransferases play essential roles in the hematopoietic sys...

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Vydáno v:eLife
Hlavní autoři: Schmidt, Kerstin, Zhang, Qinyu, Tasdogan, Alpaslan, Petzold, Andreas, Dahl, Andreas, Arneth, Borros M, Slany, Robert, Fehling, Hans Jörg, Kranz, Andrea, Stewart, Adrian Francis, Anastassiadis, Konstantinos
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2018
Témata:
Stem Cells and Regenerative Medicine
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6025962/
https://ncbi.nlm.nih.gov/pubmed/29916805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.27157
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