Long-term antigen exposure irreversibly modifies metabolic requirements for T cell function

Energy metabolism is essential for T cell function. However, how persistent antigenic stimulation affects T cell metabolism is unknown. Here, we report that long-term in vivo antigenic exposure induced a specific deficit in numerous metabolic enzymes. Accordingly, T cells exhibited low basal glycoly...

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Pubblicato in:eLife
Autori principali: Bettonville, Marie, d'Aria, Stefania, Weatherly, Kathleen, Porporato, Paolo E, Zhang, Jinyu, Bousbata, Sabrina, Sonveaux, Pierre, Braun, Michel Y
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2018
Soggetti:
Immunology and Inflammation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6025959/
https://ncbi.nlm.nih.gov/pubmed/29911570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.30938
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