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Long-term antigen exposure irreversibly modifies metabolic requirements for T cell function
Energy metabolism is essential for T cell function. However, how persistent antigenic stimulation affects T cell metabolism is unknown. Here, we report that long-term in vivo antigenic exposure induced a specific deficit in numerous metabolic enzymes. Accordingly, T cells exhibited low basal glycoly...
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| Publicado en: | eLife |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
eLife Sciences Publications, Ltd
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6025959/ https://ncbi.nlm.nih.gov/pubmed/29911570 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.30938 |
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