Tryptophan fluorescence yields and lifetimes as a probe of conformational changes in human glucokinase

Five variants of glucokinase (ATP-D-hexose-6-phosphotransferase, EC 2.7.1.1) including wild type and single Trp mutants with the Trp residue at positions 65, 99, 167 and 257 were prepared. The fluorescence of Trp in all locations studied showed intensity changes when glucose bound, indicating that c...

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Vydáno v:J Fluoresc
Hlavní autoři: Zelent, Bogumil, Bialas, Chris, Gryczynski, Ignacy, Chen, Pan, Chib, Rahul, Lewerissa, Karina, Corradini, Maria G., Ludescher, Richard D., Vanderkooi, Jane M., Matschinsky, Franz M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6025808/
https://ncbi.nlm.nih.gov/pubmed/28432632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10895-017-2099-x
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