Identification of functionally relevant histidine residues in the apoptotic nuclease CAD

The caspase-activated DNase CAD (DFF40/CPAN) degrades chromosomal DNA during apoptosis. Chemical modification with DEPC inactivates the enzyme, suggesting that histidine residues play a decisive role in the catalytic mechanism of this nuclease. Sequence alignment of murine CAD with four homologous a...

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Detalhes bibliográficos

Publicado no:	Nucleic Acids Res
Principais autores:	Meiss, Gregor, Scholz, Sebastian Richard, Korn, Christian, Gimadutdinow, Oleg, Pingoud, Alfred
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 2001
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC60245/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11574671/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/29.19.3901
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