Identification of functionally relevant histidine residues in the apoptotic nuclease CAD
The caspase-activated DNase CAD (DFF40/CPAN) degrades chromosomal DNA during apoptosis. Chemical modification with DEPC inactivates the enzyme, suggesting that histidine residues play a decisive role in the catalytic mechanism of this nuclease. Sequence alignment of murine CAD with four homologous a...
Zapisane w:
| Wydane w: | Nucleic Acids Res |
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| Główni autorzy: | , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Oxford University Press
2001
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC60245/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11574671/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/29.19.3901 |
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