One-Vector System for Multiplexed CRISPR/Cas9 against Hepatitis B Virus cccDNA Utilizing High-Capacity Adenoviral Vectors

High-capacity adenoviral vectors (HCAdVs) devoid of all coding genes are powerful tools to deliver large DNA cargos into cells. Here HCAdVs were designed to deliver a multiplexed complete CRISPR/Cas9 nuclease system or a complete pair of transcription activator-like effector nucleases (TALENs) direc...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Mol Ther Nucleic Acids
Egile Nagusiak: Schiwon, Maren, Ehrke-Schulz, Eric, Oswald, Andreas, Bergmann, Thorsten, Michler, Thomas, Protzer, Ulrike, Ehrhardt, Anja
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society of Gene & Cell Therapy 2018
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6023846/
https://ncbi.nlm.nih.gov/pubmed/30195763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2018.05.006
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