Randomized, placebo controlled phase I trial of safety, pharmacokinetics, pharmacodynamics and acceptability of tenofovir and tenofovir plus levonorgestrel vaginal rings in women

To prevent the global health burdens of human immunodeficiency virus [HIV] and unintended/mistimed pregnancies, we developed an intravaginal ring [IVR] that delivers tenofovir [TFV] at ~10mg/day alone or with levonorgestrel [LNG] at ~20μg/day for 90 days. We present safety, pharmacokinetics, pharmac...

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Veröffentlicht in:PLoS One
Hauptverfasser: Thurman, Andrea Ries, Schwartz, Jill L., Brache, Vivian, Clark, Meredith R., McCormick, Timothy, Chandra, Neelima, Marzinke, Mark A., Stanczyk, Frank Z., Dezzutti, Charlene S., Hillier, Sharon L., Herold, Betsy C., Fichorova, Raina, Asin, Susana N., Rollenhagen, Christiane, Weiner, Debra, Kiser, Patrick, Doncel, Gustavo F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2018
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6023238/
https://ncbi.nlm.nih.gov/pubmed/29953547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0199778
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