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Contact prediction is hardest for the most informative contacts, but improves with the incorporation of contact potentials
Co-evolution between pairs of residues in a multiple sequence alignment (MSA) of homologous proteins has long been proposed as an indicator of structural contacts. Recently, several methods, such as direct-coupling analysis (DCA) and MetaPSICOV, have been shown to achieve impressive rates of contact...
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| Publicado no: | PLoS One |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6023208/ https://ncbi.nlm.nih.gov/pubmed/29953468 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0199585 |
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