Benzimidazoisoquinoline derivatives inhibit glioblastoma cell proliferation through down-regulating Raf/MEK/ERK and PI3K/AKT pathways

BACKGROUND: Recent studies showed that benzimidazoleisoquinolinone derivatives exhibit anticancer activity against human cancer cell lines. The aim of this study is to evaluate the anti-tumor effects and mechanisms of benzimidazoleisoquinolinones in isocitrate dehydrogenase-wildtype subtype of human...

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Gepubliceerd in:Cancer Cell Int
Hoofdauteurs: Zhang, Ya-Jun, Xu, Zhi-Gang, Li, Shi-Qiang, He, Liu-Jun, Tang, Yan, Chen, Zhong-Zhu, Yang, Dong-Lin
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2018
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Primary Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6022716/
https://ncbi.nlm.nih.gov/pubmed/29988358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12935-018-0588-x
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