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Optimization and profile calculation of ODE models using second order adjoint sensitivity analysis

MOTIVATION: Parameter estimation methods for ordinary differential equation (ODE) models of biological processes can exploit gradients and Hessians of objective functions to achieve convergence and computational efficiency. However, the computational complexity of established methods to evaluate the...

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Pubblicato in:Bioinformatics
Autori principali: Stapor, Paul, Fröhlich, Fabian, Hasenauer, Jan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6022646/
https://ncbi.nlm.nih.gov/pubmed/29949990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/bty230
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