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Optimization and profile calculation of ODE models using second order adjoint sensitivity analysis

MOTIVATION: Parameter estimation methods for ordinary differential equation (ODE) models of biological processes can exploit gradients and Hessians of objective functions to achieve convergence and computational efficiency. However, the computational complexity of established methods to evaluate the...

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Detalhes bibliográficos
Publicado no:Bioinformatics
Main Authors: Stapor, Paul, Fröhlich, Fabian, Hasenauer, Jan
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6022646/
https://ncbi.nlm.nih.gov/pubmed/29949990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/bty230
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