Influence of peroxisome proliferator-activated receptor-γ exon 2 and exon 6 and insulin receptor substrate (IRS)-1 Gly972Arg polymorphisms on insulin resistance and beta-cell function in southern mediterranean women with polycystic ovary syndrome

BACKGROUND AND OBJECTIVE: The Pro12Ala (exon 2) and His447His (exon 6) polymorphisms of PPAR-γ, and Gly972Arg polymorphism of IRS-1 have been implicated in insulin resistance (IR) and adiposity. Our aim was to investigate the influence of these polymorphisms on metabolic features of polycystic ovary...

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Detalhes bibliográficos
Publicado no:J Clin Transl Endocrinol
Main Authors: Giandalia, Annalisa, Pappalardo, Maria Angela, Russo, Giuseppina T., Romeo, Elisabetta L., Alibrandi, Angela, Di Bari, Flavia, Vita, Roberto, Cucinotta, Domenico, Benvenga, Salvatore
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6022250/
https://ncbi.nlm.nih.gov/pubmed/30013936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcte.2018.05.002
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