Deficiencies in Natural Killer Cell Numbers, Expansion, and Function at the Pre-Neoplastic Stage of Pancreatic Cancer by KRAS Mutation in the Pancreas of Obese Mice

The combined/synergistic effect of genetic mutation of KRAS in the pancreas and obesity, a life-style factor on suppression of natural killer (NK) cells at the pre-neoplastic stage of pancreatic cancer has not been investigated and is the subject of this report. Obese mice with KRAS (KC) mutation in...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Kaur, Kawaljit, Chang, Hui-Hua, Topchyan, Paytsar, Cook, Jessica Morgan, Barkhordarian, Andre, Eibl, Guido, Jewett, Anahid
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6021953/
https://ncbi.nlm.nih.gov/pubmed/29977235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01229
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