Antibacterial Activity of Human Simulated Epithelial Lining Fluid Concentrations of Ceftazidime-Avibactam Alone or in Combination with Amikacin Inhale (BAY41-6551) against Carbapenem-Resistant Pseudomonas aeruginosa and Klebsiella pneumoniae

The role of inhalational combination therapy when treating carbapenem-resistant Pseudomonas aeruginosa and Klebsiella pneumoniae with newer beta-lactam/beta-lactamase inhibitors has not been established. Using a 72-h in vitro pharmacodynamic chemostat model, we simulated the human exposures achieved...

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Publicat a:Antimicrob Agents Chemother
Autors principals: Almarzoky Abuhussain, Safa S., Kuti, Joseph L., Nicolau, David P.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2018
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6021645/
https://ncbi.nlm.nih.gov/pubmed/29914950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00113-18
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