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In Vitro Evolution of Antibodies Inspired by In Vivo Evolution

In vitro generation of antibodies often requires variable domain sequence evolution to adapt the protein in terms of affinity, specificity, or developability. Such antibodies, including those that are of interest for clinical development, may have their origins in a diversity of immunoglobulin germl...

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Bibliografische gegevens
Gepubliceerd in:Front Immunol
Hoofdauteurs: Persson, Helena, Kirik, Ufuk, Thörnqvist, Linnea, Greiff, Lennart, Levander, Fredrik, Ohlin, Mats
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2018
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6021498/
https://ncbi.nlm.nih.gov/pubmed/29977238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01391
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