The pharmacological perturbation of brain zinc impairs BDNF-related signaling and the cognitive performances of young mice

Zinc (Zn(2+)) is a pleiotropic modulator of the neuronal and brain activity. The disruption of intraneuronal Zn(2+) levels triggers neurotoxic processes and affects neuronal functioning. In this study, we investigated how the pharmacological modulation of brain Zn(2+) affects synaptic plasticity and...

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Publicado no:Sci Rep
Main Authors: Frazzini, Valerio, Granzotto, Alberto, Bomba, Manuela, Massetti, Noemi, Castelli, Vanessa, d’Aurora, Marco, Punzi, Miriam, Iorio, Mariangela, Mosca, Alessandra, Delli Pizzi, Stefano, Gatta, Valentina, Cimini, Annamaria, Sensi, Stefano L.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6021411/
https://ncbi.nlm.nih.gov/pubmed/29950603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-28083-9
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