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Inhibition of de novo ceramide biosynthesis affects aging phenotype in an in vitro model of neuronal senescence

Although aging is considered to be an unavoidable event, recent experimental evidence suggests that the process can be counteracted. Intracellular calcium (Ca(2+)(i)) dyshomeostasis, mitochondrial dysfunction, oxidative stress, and lipid dysregulation are critical factors that contribute to senescen...

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Detalhes bibliográficos
Publicado no:Aging (Albany NY)
Main Authors: Granzotto, Alberto, Bomba, Manuela, Castelli, Vanessa, Navarra, Riccardo, Massetti, Noemi, d’Aurora, Marco, Onofrj, Marco, Cicalini, Ilaria, del Boccio, Piero, Gatta, Valentina, Cimini, Annamaria, Piomelli, Daniele, Sensi, Stefano L.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6738398/
https://ncbi.nlm.nih.gov/pubmed/31467258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.102191
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