The role of acetylation in rDNA transcription

Treatment of NIH 3T3 cells with trichostatin A (TSA), an inhibitor of histone deacetylase (HDAC), resulted in a dose-dependent increase in transcription from a rDNA reporter and from endogenous rRNA genes. Chromatin immunoprecipitation using anti-acetyl-histone H4 antibodies demonstrated a direct ef...

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Bibliographic Details
Main Authors: Hirschler-Laszkiewicz, Iwona, Cavanaugh, Alice, Hu, Qiyue, Catania, Jason, Avantaggiati, Maria Laura, Rothblum, Lawrence I.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2001
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC60214/
https://ncbi.nlm.nih.gov/pubmed/11600700
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