CREPT facilitates colorectal cancer growth through inducing Wnt/β-catenin pathway by enhancing p300-mediated β-catenin acetylation

Using whole genome sequencing, we identified gene amplification of CREPT in colorectal cancer (CRC). In this study, we aim to clarify its clinical significance, biological effects, and mechanism in CRC. CREPT was upregulated in CRC cell lines and in 47.37% (72/152) of primary CRC tumors. Amplificati...

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Enregistré dans:
Détails bibliographiques
Publié dans:Oncogene
Auteurs principaux: Zhang, Yanquan, Wang, Shiyan, Kang, Wei, Liu, Chunxiao, Dong, Yujuan, Ren, Fangli, Wang, Yinyin, Zhang, Jinglin, Wang, Guoping, To, Ka Fai, Zhang, Xueji, Sung, Joseph JY, Chang, Zhijie, Yu, Jun
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2018
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6021369/
https://ncbi.nlm.nih.gov/pubmed/29563608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0161-z
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