CREPT facilitates colorectal cancer growth through inducing Wnt/β-catenin pathway by enhancing p300-mediated β-catenin acetylation

Using whole genome sequencing, we identified gene amplification of CREPT in colorectal cancer (CRC). In this study, we aim to clarify its clinical significance, biological effects, and mechanism in CRC. CREPT was upregulated in CRC cell lines and in 47.37% (72/152) of primary CRC tumors. Amplificati...

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Publicado en:Oncogene
Autores principales: Zhang, Yanquan, Wang, Shiyan, Kang, Wei, Liu, Chunxiao, Dong, Yujuan, Ren, Fangli, Wang, Yinyin, Zhang, Jinglin, Wang, Guoping, To, Ka Fai, Zhang, Xueji, Sung, Joseph JY, Chang, Zhijie, Yu, Jun
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6021369/
https://ncbi.nlm.nih.gov/pubmed/29563608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0161-z
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