Synthesis Facilitates an Understanding of the Structural Basis for Translation Inhibition by the Lissoclimides

The lissoclimides are unusual succinimide-containing labdane diterpenoids that were reported to be potent cytotoxins. Our short semi-synthesis and analogue-oriented synthesis approaches have provided a series of lissoclimide natural products and analogues that expanded the structure-activity relatio...

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Publicat a:Nat Chem
Autors principals: Könst, Zef A., Szklarski, Anne R., Pellegrino, Simone, Michalak, Sharon E., Meyer, Mélanie, Zanette, Camila, Cencic, Regina, Nam, Sangkil, Voora, Vamsee, Horne, David A., Pelletier, Jerry, Mobley, David L., Yusupova, Gulnara, Yusupov, Marat, Vanderwal, Christopher D.
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6021127/
https://ncbi.nlm.nih.gov/pubmed/29064494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchem.2800
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