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Structure of PINK1 in complex with its substrate ubiquitin
Autosomal recessive juvenile Parkinsonism (AR-JP) is caused by mutations in a number of PARK genes, in particular in the E3 ubiquitin ligase Parkin (PARK2), and in its upstream protein kinase PINK1 (PARK6). PINK1 phosphorylates ubiquitin and the Parkin ubiquitin-like domain on structurally protected...
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| Publicat a: | Nature |
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| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6020998/ https://ncbi.nlm.nih.gov/pubmed/29160309 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature24645 |
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