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Functional variomics and network perturbation: connecting genotype to phenotype in cancer
Proteins interact with other macromolecules in complex cellular networks for signal transduction and biological function. In cancer, genetic aberrations have been traditionally thought to disrupt the entire gene function. It has been increasingly appreciated that each mutation of a gene could have a...
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| Pubblicato in: | Nat Rev Genet |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6020840/ https://ncbi.nlm.nih.gov/pubmed/28344341 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrg.2017.8 |
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