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Gene promoter and exon DNA methylation changes in colon cancer development – mRNA expression and tumor mutation alterations
BACKGROUND: DNA mutations occur randomly and sporadically in growth-related genes, mostly on cytosines. Demethylation of cytosines may lead to genetic instability through spontaneous deamination. Aims were whole genome methylation and targeted mutation analysis of colorectal cancer (CRC)-related gen...
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| Published in: | BMC Cancer |
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| Main Authors: | , , , , , , , , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
BioMed Central
2018
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6020382/ https://ncbi.nlm.nih.gov/pubmed/29945573 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-018-4609-x |
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