Gene promoter and exon DNA methylation changes in colon cancer development – mRNA expression and tumor mutation alterations

BACKGROUND: DNA mutations occur randomly and sporadically in growth-related genes, mostly on cytosines. Demethylation of cytosines may lead to genetic instability through spontaneous deamination. Aims were whole genome methylation and targeted mutation analysis of colorectal cancer (CRC)-related gen...

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Bibliographic Details
Published in:BMC Cancer
Main Authors: Molnár, Béla, Galamb, Orsolya, Péterfia, Bálint, Wichmann, Barnabás, Csabai, István, Bodor, András, Kalmár, Alexandra, Szigeti, Krisztina Andrea, Barták, Barbara Kinga, Nagy, Zsófia Brigitta, Valcz, Gábor, Patai, Árpád V., Igaz, Péter, Tulassay, Zsolt
Format: Artigo
Language:Inglês
Published: BioMed Central 2018
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6020382/
https://ncbi.nlm.nih.gov/pubmed/29945573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-018-4609-x
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