Inflammation down-regulates CYP3A4-catalysed drug metabolism in hemodialysis patients

BACKGROUND: Recent studies indicate that inflammation may also affect CYP3A4 activity. Associations of CYP3A4-mediated metabolism of quinine, with inflammatory biomarkers were investigated in patients undergoing maintenance hemodialysis (HD). METHODS: A single dose of 100 mg quinine was given to 44...

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Bibliographic Details
Published in:BMC Pharmacol Toxicol
Main Authors: Molanaei, Hadi, Qureshi, Abdul Rashid, Heimbürger, Olof, Lindholm, Bengt, Diczfalusy, Ulf, Anderstam, Björn, Bertilsson, Leif, Stenvinkel, Peter
Format: Artigo
Language:Inglês
Published: BioMed Central 2018
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6020207/
https://ncbi.nlm.nih.gov/pubmed/29941014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40360-018-0221-6
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