High MITF Expression Is Associated with Super-Enhancers and Suppressed by CDK7 Inhibition in Melanoma

Cutaneous melanoma is an aggressive tumor that accounts for most skin cancer deaths. Among the physiological barriers against therapeutic success is a strong survival program driven by genes such as MITF that specify melanocyte identity, a phenomenon known in melanoma biology as lineage dependency....

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Bibliographic Details
Published in:J Invest Dermatol
Main Authors: Eliades, Philip, Abraham, Brian J., Ji, Zhenyu, Miller, David M., Christensen, Camilla L., Kwiatkowski, Nicholas, Kumar, Raj, Njauw, Ching Ni, Taylor, Michael, Miao, Benchun, Zhang, Tinghu, Wong, Kwok-Kin, Gray, Nathanael S., Young, Richard A., Tsao, Hensin
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6019629/
https://ncbi.nlm.nih.gov/pubmed/29408204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jid.2017.09.056
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