Molecular Mechanisms for the Adaptive Switching Between the OAS/RNase L and OASL/RIG-I Pathways in Birds and Mammals

Host cells develop the OAS/RNase L [2′–5′–oligoadenylate synthetase (OAS)/ribonuclease L] system to degrade cellular and viral RNA, and/or the OASL/RIG-I (2′–5′–OAS like/retinoic acid inducible protein I) system to enhance RIG-I-mediated IFN induction, thus providing the first line of defense agains...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Rong, Enguang, Wang, Xiaoxue, Chen, Hualan, Yang, Chenghuai, Hu, Jiaxiang, Liu, Wenjie, Wang, Zeng, Chen, Xiaoyun, Zheng, Haixue, Pu, Juan, Sun, Honglei, Smith, Jacqueline, Burt, David W., Liu, Jinhua, Li, Ning, Huang, Yinhua
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6019448/
https://ncbi.nlm.nih.gov/pubmed/29973937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01398
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