Co-culturing nucleus pulposus mesenchymal stem cells with notochordal cell-rich nucleus pulposus explants attenuates tumor necrosis factor-α-induced senescence

BACKGROUND: Cell therapy for the treatment of intervertebral disc degeneration (IDD) faces serious barriers since tissue-specific adult cells such as nucleus pulposus cells (NPCs) have limited proliferative ability and poor regenerative potential; in addition, it is difficult for exogenous adult ste...

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Veröffentlicht in:Stem Cell Res Ther
Hauptverfasser: Li, Xiao-Chuan, Wang, Mao-Sheng, Liu, Wei, Zhong, Cheng-Fan, Deng, Gui-Bin, Luo, Shao-Jian, Huang, Chun-Ming
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2018
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6019307/
https://ncbi.nlm.nih.gov/pubmed/29941029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-018-0919-9
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