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Enantioselective Synthesis of Trisubstituted Allenyl–B(pin) Compounds by Phosphine–Cu-Catalyzed 1,3-Enyne Hydroboration. Insights Regarding Stereochemical Integrity of Cu–Allenyl Intermediates

Catalytic enantioselective boron–hydride additions to 1,3-enynes, which afford allenyl–B(pin) (pin = pinacolato) products, are disclosed. Transformations are promoted by a readily accessible bis-phosphine–Cu complex and involve commercially available HB(pin). The method is applicable to aryl- and al...

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Detalles Bibliográficos
Publicado en:J Am Chem Soc
Autores principales: Huang, Youming, del Pozo, Juan, Torker, Sebastian, Hoveyda, Amir H.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6019291/
https://ncbi.nlm.nih.gov/pubmed/29417810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b13296
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