STAT4 is required for the generation of T(h)1 and T(h)2, but not T(h)17 immune responses during monophosphoryl lipid A adjuvant activity

STAT4 is critical for the production of IFN-γ during the generation of T(h)1 immune responses. We investigated the role of STAT4 in mediating T(h)1-inducing activity of a vaccine adjuvant monophosphoryl lipid A (MPL-A) using the standard antigen ovalbumin (OVA) in STAT4KO mice. Our results show that...

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Detalhes bibliográficos
Publicado no:Int Immunol
Main Authors: Varikuti, Sanjay, Oghumu, Steve, Natarajan, Gayathri, Kimble, Jennifer, Sperling, Rachel H, Moretti, Ellen, Kaplan, Mark H, Satoskar, Abhay R
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Short Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6018885/
https://ncbi.nlm.nih.gov/pubmed/27578456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/intimm/dxw038
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