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In vitro 3′-end endonucleolytic processing defect in a human mitochondrial tRNA(Ser(UCN)) precursor with the U7445C substitution, which causes non-syndromic deafness
Eukaryotic tRNAs are transcribed as precursors. A 5′-end leader and 3′-end trailer are endonucleolytically removed by RNase P and 3′-tRNase before 3′-end CCA addition, aminoacylation, nuclear export and translation. 3′-End -CC can be a 3′-tRNase anti-determinant with the ability to prevent mature tR...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Oxford University Press
2001
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC60182/ https://ncbi.nlm.nih.gov/pubmed/11691920 |
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