In vitro 3′-end endonucleolytic processing defect in a human mitochondrial tRNA(Ser(UCN)) precursor with the U7445C substitution, which causes non-syndromic deafness
Eukaryotic tRNAs are transcribed as precursors. A 5′-end leader and 3′-end trailer are endonucleolytically removed by RNase P and 3′-tRNase before 3′-end CCA addition, aminoacylation, nuclear export and translation. 3′-End -CC can be a 3′-tRNase anti-determinant with the ability to prevent mature tR...
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| Опубликовано в:: | Nucleic Acids Res |
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| Главные авторы: | , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Oxford University Press
2001
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC60182/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11691920/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/29.21.4334 |
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