Mitochondrial DNA deletion mutations are concomitant with ragged red regions of individual, aged muscle fibers: analysis by laser-capture microdissection

Laser-capture microdissection was coupled with PCR to define the mitochondrial genotype of aged muscle fibers exhibiting mitochondrial enzymatic abnormalities. These electron transport system (ETS) abnormalities accumulate with age, are localized segmentally along muscle fibers, are associated with...

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Main Authors: Cao, Zhengjin, Wanagat, Jonathan, McKiernan, Susan H., Aiken, Judd M.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2001
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC60181/
https://ncbi.nlm.nih.gov/pubmed/11691938
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