RATIONAL ENGINEERING AND CHARACTERIZATION OF AN MAB THAT NEUTRALIZES ZIKA VIRUS BY TARGETING A MUTATIONALLY CONSTRAINED QUATERNARY EPITOPE

Following the recent emergence of Zika virus (ZIKV), many murine and human neutralizing anti-ZIKV antibodies have been reported. Given the risk of virus escape mutants, engineering antibodies that target mutationally constrained epitopes with therapeutically relevant potencies can be valuable for co...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Cell Host Microbe
Autores principales: Tharakaraman, Kannan, Watanabe, Satoru, Chan, Kuan Rong, Huan, Jia, Subramanian, Vidya, Chionh, Yok Hian, Raguram, Aditya, Quinlan, Devin, McBee, Megan, Ong, Eugenia Z, Gan, Esther S, Tan, Hwee Cheng, Tyagi, Anu, Bhushan, Shashi, Lescar, Julien, Vasudevan, Subhash G., Ooi, Eng Eong, Sasisekharan, Ram
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6018055/
https://ncbi.nlm.nih.gov/pubmed/29746833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2018.04.004
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares