A Novel Class of Schistosoma mansoni Histone Deacetylase 8 (HDAC8) Inhibitors Identified by Structure-Based Virtual Screening and In Vitro Testing

A promising means in the search of new small molecules for the treatment of schistosomiasis (amongst other parasitic ailments) is by targeting the parasitic epigenome. In the present study, a docking based virtual screening procedure using the crystal structure of histone deacetylase 8 from Schistos...

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Publicado en:Molecules
Main Authors: Simoben, Conrad V., Robaa, Dina, Chakrabarti, Alokta, Schmidtkunz, Karin, Marek, Martin, Lancelot, Julien, Kannan, Srinivasaraghavan, Melesina, Jelena, Shaik, Tajith B., Pierce, Raymond J., Romier, Christophe, Jung, Manfred, Sippl, Wolfgang
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6017931/
https://ncbi.nlm.nih.gov/pubmed/29498707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules23030566
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