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Synthesis and Smo Activity of Some Novel Benzamide Derivatives

Two series of benzamides compounds bearing piperidine groups were synthesized and the Gli-luc luciferase activity was screened by Gys-luc luciferase gene detection method. Compound 5q showed promising inhibition of hedgehog (Hh) signaling pathway. To further verify whether the Hh inhibitory activiti...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Ding, Huaiwei, Chen, Kai, Song, Bingke, Deng, Chenglong, Li, Wei, Niu, Li, Bai, Mengxuan, Song, Hongrui, Zhang, Lijuan
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6017536/
https://ncbi.nlm.nih.gov/pubmed/29301237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules23010085
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