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A folded viral noncoding RNA blocks host cell exoribonucleases through a conformationally dynamic RNA structure

Folded RNA elements that block processive 5′ → 3′ cellular exoribonucleases (xrRNAs) to produce biologically active viral noncoding RNAs have been discovered in flaviviruses, potentially revealing a new mode of RNA maturation. However, whether this RNA structure-dependent mechanism exists elsewhere...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Steckelberg, Anna-Lena, Akiyama, Benjamin M., Costantino, David A., Sit, Tim L., Nix, Jay C., Kieft, Jeffrey S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6016793/
https://ncbi.nlm.nih.gov/pubmed/29866852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1802429115
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