Suppression of Viral RNA Recombination by a Host Exoribonuclease

RNA viruses of humans, animals, and plants evolve rapidly due to mutations and RNA recombination. A previous genome-wide screen in Saccharomyces cerevisiae, a model host, identified five host genes, including XRN1, encoding a 5′-3′ exoribonuclease, whose absence led to an ∼10- to 50-fold enhancement...

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Bibliographic Details
Main Authors: Cheng, Chi-Ping, Serviene, Elena, Nagy, Peter D.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2006
Subjects:
Genome Replication and Regulation of Viral Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1395426/
https://ncbi.nlm.nih.gov/pubmed/16501073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.80.6.2631-2640.2006
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