In vitro biomimetic engineering of a human hematopoietic niche with functional properties

In adults, human hematopoietic stem and progenitor cells (HSPCs) reside in the bone marrow (BM) microenvironment. Our understanding of human hematopoiesis and the associated niche biology remains limited, due to human material accessibility and limits of existing in vitro culture models. The establi...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Bourgine, Paul E., Klein, Thibaut, Paczulla, Anna M., Shimizu, Takafumi, Kunz, Leo, Kokkaliaris, Konstantinos D., Coutu, Daniel L., Lengerke, Claudia, Skoda, Radek, Schroeder, Timm, Martin, Ivan
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2018
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6016789/
https://ncbi.nlm.nih.gov/pubmed/29866839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1805440115
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