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A widespread bacterial phenazine forms S-conjugates with biogenic thiols and crosslinks proteins

Phenazines are redox-active compounds produced by a range of bacteria, including many pathogens. Endowed with various biological activities, these ubiquitous N-heterocycles are well known for their ability to generate reactive oxygen species by redox cycling. Phenazines may lead to an irreversible d...

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Detalhes bibliográficos
Publicado no:Chem Sci
Main Authors: Heine, D., Sundaram, S., Beudert, Matthias, Martin, K., Hertweck, C.
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6016718/
https://ncbi.nlm.nih.gov/pubmed/30155132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6sc00503a
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