The opioid oxycodone use‐dependently inhibits the cardiac sodium channel Na(V)1.5

BACKGROUND AND PURPOSE: Oxycodone is a potent semi‐synthetic opioid that is commonly used for the treatment of severe acute and chronic pain. However, treatment with oxycodone can lead to cardiac electrical changes, such as long QT syndrome, potentially inducing sudden cardiac arrest. Here, we inves...

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Bibliografiske detaljer
Udgivet i:Br J Pharmacol
Main Authors: Meents, Jannis E, Juhasz, Krisztina, Stölzle‐Feix, Sonja, Peuckmann‐Post, Vera, Rolke, Roman, Lampert, Angelika
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2018
Fag:
Research Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6016641/
https://ncbi.nlm.nih.gov/pubmed/29722437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14348
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