The opioid oxycodone use‐dependently inhibits the cardiac sodium channel Na(V)1.5

BACKGROUND AND PURPOSE: Oxycodone is a potent semi‐synthetic opioid that is commonly used for the treatment of severe acute and chronic pain. However, treatment with oxycodone can lead to cardiac electrical changes, such as long QT syndrome, potentially inducing sudden cardiac arrest. Here, we inves...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Meents, Jannis E, Juhasz, Krisztina, Stölzle‐Feix, Sonja, Peuckmann‐Post, Vera, Rolke, Roman, Lampert, Angelika
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6016641/
https://ncbi.nlm.nih.gov/pubmed/29722437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14348
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