A computational approach for predicting off-target toxicity of antiviral ribonucleoside analogues to mitochondrial RNA polymerase

In the development of antiviral drugs that target viral RNA-dependent RNA polymerases, off-target toxicity caused by the inhibition of the human mitochondrial RNA polymerase (POLRMT) is a major liability. Therefore, it is essential that all new ribonucleoside analogue drugs be accurately screened fo...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Freedman, Holly, Winter, Philip, Tuszynski, Jack, Tyrrell, D. Lorne, Houghton, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Computational Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6016467/
https://ncbi.nlm.nih.gov/pubmed/29739852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002588
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