Antiviral Nucleotide Incorporation by Recombinant Human Mitochondrial RNA Polymerase Is Predictive of Increased In Vivo Mitochondrial Toxicity Risk

Nucleoside or nucleotide inhibitors are a highly successful class of antivirals due to selectivity, potency, broad coverage, and high barrier to resistance. Nucleosides are the backbone of combination treatments for HIV, hepatitis B virus, and, since the FDA approval of sofosbuvir in 2013, also for...

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Bibliografiset tiedot
Julkaisussa:Antimicrob Agents Chemother
Päätekijät: Fenaux, Martijn, Lin, Xiaodong, Yokokawa, Fumiaki, Sweeney, Zachary, Saunders, Oliver, Xie, Lili, Lim, Siew Pheng, Uteng, Marianne, Uehara, Kyoko, Warne, Robert, Gang, Wang, Jones, Christopher, Yendluri, Satya, Gu, Helen, Mansfield, Keith, Boisclair, Julie, Heimbach, Tycho, Catoire, Alexandre, Bracken, Kathryn, Weaver, Margaret, Moser, Heinz, Zhong, Weidong
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology 2016
Aiheet:
Antiviral Agents
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5118986/
https://ncbi.nlm.nih.gov/pubmed/27645237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01253-16
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