Antiviral Nucleotide Incorporation by Recombinant Human Mitochondrial RNA Polymerase Is Predictive of Increased In Vivo Mitochondrial Toxicity Risk

Nucleoside or nucleotide inhibitors are a highly successful class of antivirals due to selectivity, potency, broad coverage, and high barrier to resistance. Nucleosides are the backbone of combination treatments for HIV, hepatitis B virus, and, since the FDA approval of sofosbuvir in 2013, also for...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Fenaux, Martijn, Lin, Xiaodong, Yokokawa, Fumiaki, Sweeney, Zachary, Saunders, Oliver, Xie, Lili, Lim, Siew Pheng, Uteng, Marianne, Uehara, Kyoko, Warne, Robert, Gang, Wang, Jones, Christopher, Yendluri, Satya, Gu, Helen, Mansfield, Keith, Boisclair, Julie, Heimbach, Tycho, Catoire, Alexandre, Bracken, Kathryn, Weaver, Margaret, Moser, Heinz, Zhong, Weidong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5118986/
https://ncbi.nlm.nih.gov/pubmed/27645237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01253-16
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