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Divergent enantioselective synthesis of hapalindole-type alkaloids using catalytic asymmetric hydrogenation of a ketone to construct the chiral core structure

A divergent enantioselective approach to hapalindole-type alkaloids is described. The route features a ruthenium-catalyzed asymmetric hydrogenation of a ketone via DKR to construct the chiral trans-1-indolyl-2-isopropenylcyclohexane skeleton and a switchable sequence of methylation and acetylation/a...

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Bibliografiske detaljer
Udgivet i:Chem Sci
Main Authors: Liu, Yang, Cheng, Li-Jie, Yue, Hai-Tao, Che, Wen, Xie, Jian-Hua, Zhou, Qi-Lin
Format: Artigo
Sprog:Inglês
Udgivet: Royal Society of Chemistry 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6016446/
https://ncbi.nlm.nih.gov/pubmed/30155122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6sc00686h
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