TNF Receptor Type II as an Emerging Drug Target for the Treatment of Cancer, Autoimmune Diseases, and Graft-Versus-Host Disease: Current Perspectives and In Silico Search for Small Molecule Binders

There is now compelling evidence that TNF receptor type II (TNFR2) is predominantly expressed on CD4(+)Foxp3(+) regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs), and plays a major role in the expansion and function of Tregs and MDSCs. Consequently, targeting of TNFR2 by either...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Shaikh, Faraz, He, Jiang, Bhadra, Pratiti, Chen, Xin, Siu, Shirley W. I.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6015900/
https://ncbi.nlm.nih.gov/pubmed/29967617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01382
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