IgG Fc domains that bind C1q but not effector Fcγ receptors delineate the importance of complement-mediated effector functions

Engineered crystallizable fragment (Fc) regions of antibody domains, which assume a unique and unprecedented asymmetric structure within the homodimeric Fc polypeptide, enable completely selective binding to the complement component C1q and activation of complement via the classical pathway without...

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Udgivet i:Nat Immunol
Main Authors: Lee, Chang-Han, Romain, Gabrielle, Yan, Wupeng, Watanabe, Makiko, Charab, Wissam, Todorova, Biliana, Lee, Jiwon, Triplett, Kendra, Donkor, Moses, Lungu, Oana I, Lux, Anja, Marshall, Nicholas, Lindorfer, Margaret A, Goff, Odile Richard-Le, Balbino, Bianca, Kang, Tae Hyun, Tanno, Hidetaka, Delidakis, George, Alford, Corrine, Taylor, Ronald P, Nimmerjahn, Falk, Varadarajan, Navin, Bruhns, Pierre, Zhang, Yan Jessie, Georgiou, George
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6015732/
https://ncbi.nlm.nih.gov/pubmed/28604720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3770
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